PP cell

PP cell (also known as Pancreatic Polypeptide cell or F cell) is a type of cell in the pancreas that secretes the hormone pancreatic polypeptide (PP). These cells are located in the Islets of Langerhans, which are tiny clusters of cells scattered throughout the pancreas.

Structure

PP cells are found predominantly in the pancreas, specifically in the Islets of Langerhans. They make up approximately 20-30% of the islet cells. They are more abundant in the head of the pancreas than in the tail.

Function

The primary function of PP cells is to secrete the hormone pancreatic polypeptide. This hormone is involved in the regulation of pancreatic secretion and gastrointestinal motility. It is released in response to fasting, protein-rich meals, and acetylcholine.

Clinical significance

Abnormalities in PP cells can lead to various medical conditions. For example, a tumor of the PP cells, known as a PPoma, is a rare type of neuroendocrine tumor. Symptoms of a PPoma can include abdominal pain, weight loss, and diabetes mellitus.

See also

• Pancreas
• Islets of Langerhans
• Pancreatic polypeptide
• PPoma