PRB4
PRB4
PRB4 is a gene that encodes a protein known as prenylated Rab acceptor 1 (PRA1). This gene is located on chromosome 9 in humans. The PRA1 protein plays a crucial role in intracellular protein trafficking and membrane fusion processes.
Function[edit | edit source]
The PRB4 gene encodes the PRA1 protein, which is involved in the prenylation of Rab GTPases. Prenylation is a post-translational modification that involves the addition of lipid groups to proteins, allowing them to anchor to cellular membranes. PRA1 specifically interacts with prenylated Rab proteins, facilitating their proper localization and function in membrane trafficking pathways.
Clinical Significance[edit | edit source]
Mutations in the PRB4 gene have been associated with certain genetic disorders and diseases. Disruption of PRA1 function can lead to defects in intracellular trafficking processes, which may contribute to the pathogenesis of certain conditions.
Interactions[edit | edit source]
The PRA1 protein interacts with various other proteins involved in membrane trafficking and vesicle transport pathways. These interactions are essential for the proper functioning of intracellular membrane dynamics and organelle biogenesis.
References[edit | edit source]
 | This food-related article is a stub. You can help WikiMD by expanding it. |
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD
