PROP1

From WikiMD's Wellness Encyclopedia

PROP1 (Prophet of Pit-1) is a protein that in humans is encoded by the PROP1 gene. This protein is involved in the early development of the pituitary gland and plays a crucial role in the production of hormones that control growth, sexual development, and metabolism.

Function[edit | edit source]

The PROP1 gene provides instructions for making a protein that is involved in the development of the pituitary gland. This protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. Researchers believe that the PROP1 protein is involved in the formation of several types of hormone-producing cells in the pituitary gland.

Clinical significance[edit | edit source]

Mutations in the PROP1 gene are responsible for a form of combined pituitary hormone deficiency (CPHD). This condition is characterized by a shortage (deficiency) of several hormones, which disrupts normal growth, sexual development, and metabolism. People with CPHD due to PROP1 mutations often have an underdeveloped or absent pituitary gland.

Genetics[edit | edit source]

The PROP1 gene is located on the short (p) arm of chromosome 5 at position 13.2. More precisely, the PROP1 gene is located from base pair 38,010,789 to base pair 38,012,725 on chromosome 5.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD