PROX2

PROX2 or Prospero homeobox 2 is a protein that in humans is encoded by the PROX2 gene. This protein is a member of the homeobox family of genes, which play a crucial role in cellular differentiation and morphogenesis during embryonic development.

Function

The PROX2 gene is a transcription factor that is involved in the development of several organ systems, including the lymphatic system, eye, heart, and central nervous system. It is also implicated in the regulation of cell cycle and apoptosis.

Clinical significance

Mutations in the PROX2 gene have been associated with various medical conditions. For instance, they have been linked to aniridia, a rare congenital eye disorder characterized by the absence of the iris. Additionally, aberrant expression of PROX2 has been observed in several types of cancer, including breast cancer and colorectal cancer.

Research

Research into the role of PROX2 in disease is ongoing. Current studies are focused on understanding the molecular mechanisms by which PROX2 regulates cellular processes and contributes to disease pathogenesis. This knowledge could potentially be used to develop new therapeutic strategies for diseases associated with PROX2 dysfunction.

See also

• Homeobox
• Transcription factor
• Aniridia
• Breast cancer
• Colorectal cancer