PTEN
PTEN (Phosphatase and tensin homolog) is a protein that in humans is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers.
Function[edit | edit source]
PTEN is a protein tyrosine phosphatase that is involved in the regulation of the cell cycle. It is able to regulate cell cycle progression and cell survival by dephosphorylating phosphatidylinositol (3,4,5)-trisphosphate (PIP3), an activator of AKT.
Clinical significance[edit | edit source]
Mutations in this gene have been associated with Cowden syndrome, Lhermitte-Duclos disease, and other cancers. PTEN mutation also causes a variety of inherited predispositions to cancer.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- PTEN at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
