PTEN

PTEN (Phosphatase and tensin homolog) is a protein that in humans is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers.

Function

PTEN is a protein tyrosine phosphatase that is involved in the regulation of the cell cycle. It is able to regulate cell cycle progression and cell survival by dephosphorylating phosphatidylinositol (3,4,5)-trisphosphate (PIP3), an activator of AKT.

Clinical significance

Mutations in this gene have been associated with Cowden syndrome, Lhermitte-Duclos disease, and other cancers. PTEN mutation also causes a variety of inherited predispositions to cancer.

See also

• Tumor suppressor gene
• Oncogene

External links

• PTEN at the US National Library of Medicine Medical Subject Headings (MeSH)

PTEN Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski