PTGES3

PTGES3 (Prostaglandin E Synthase 3) is a gene in humans that encodes the protein Prostaglandin E Synthase 3. This protein is involved in the biosynthesis of prostaglandin E2 (PGE2), a bioactive lipid that plays a key role in inflammation, fever, and pain.

Function

The PTGES3 gene encodes a protein that functions as a co-chaperone in the Hsp90 (Heat Shock Protein 90) complex. This complex is essential for the proper folding and function of various client proteins, including steroid hormone receptors, kinases, and other signaling molecules. PTGES3 specifically facilitates the conversion of prostaglandin H2 (PGH2) to PGE2, a critical step in the prostaglandin biosynthetic pathway.

Clinical Significance

Alterations in the PTGES3 gene have been implicated in various diseases and conditions. Overexpression of PTGES3 has been observed in certain types of cancer, suggesting a potential role in tumorigenesis. Additionally, PTGES3 may be involved in inflammatory diseases due to its role in PGE2 production.

Interactions

PTGES3 interacts with several proteins within the Hsp90 complex, including Hsp90, p23, and other co-chaperones. These interactions are crucial for the stability and function of the Hsp90 complex and its client proteins.

Related Pages

• Prostaglandin
• Hsp90
• Inflammation
• Cancer
• Steroid hormone receptor