PVRL3
PVRL3 (PVR Like 3), also known as Nectin-3, is a protein that in humans is encoded by the PVRL3 gene. It is a member of the Nectin and Nectin-like (Necl) family of proteins, which function as cell adhesion molecules (CAMs) at adherens junctions.
Function[edit | edit source]
PVRL3 is a cell adhesion protein which is required for apoptosis induction by the adenovirus E4-ORF4 protein. The protein is a component of adherens junctions, which are complexes that occur at cell-cell junctions and regulate cell growth and polarity. It is also involved in the formation of synapses between neurons.
Clinical significance[edit | edit source]
Mutations in the PVRL3 gene have been associated with Cleft lip and palate and ectodermal dysplasia in humans. The protein is also a potential target for cancer therapy, as it is overexpressed in several types of cancer, including breast cancer, ovarian cancer, and lung cancer.
Interactions[edit | edit source]
PVRL3 has been shown to interact with:
- Afadin, a protein that is involved in the formation of adherens junctions
- Nectin-1 and Nectin-2, which are other members of the Nectin family
- CD155, a protein that is involved in cell adhesion and serves as a receptor for poliovirus
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- PVRL3 at the National Center for Biotechnology Information
PVRL3 Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD