PVRL3

From WikiMD's Wellness Encyclopedia

PVRL3 (PVR Like 3), also known as Nectin-3, is a protein that in humans is encoded by the PVRL3 gene. It is a member of the Nectin and Nectin-like (Necl) family of proteins, which function as cell adhesion molecules (CAMs) at adherens junctions.

Function[edit | edit source]

PVRL3 is a cell adhesion protein which is required for apoptosis induction by the adenovirus E4-ORF4 protein. The protein is a component of adherens junctions, which are complexes that occur at cell-cell junctions and regulate cell growth and polarity. It is also involved in the formation of synapses between neurons.

Clinical significance[edit | edit source]

Mutations in the PVRL3 gene have been associated with Cleft lip and palate and ectodermal dysplasia in humans. The protein is also a potential target for cancer therapy, as it is overexpressed in several types of cancer, including breast cancer, ovarian cancer, and lung cancer.

Interactions[edit | edit source]

PVRL3 has been shown to interact with:

  • Afadin, a protein that is involved in the formation of adherens junctions
  • Nectin-1 and Nectin-2, which are other members of the Nectin family
  • CD155, a protein that is involved in cell adhesion and serves as a receptor for poliovirus

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

  • PVRL3 at the National Center for Biotechnology Information
PVRL3 Resources
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD