PVRL3
PVRL3 (PVR Like 3), also known as Nectin-3, is a protein that in humans is encoded by the PVRL3 gene. It is a member of the Nectin and Nectin-like (Necl) family of proteins, which function as cell adhesion molecules (CAMs) at adherens junctions.
Function[edit | edit source]
PVRL3 is a cell adhesion protein which is required for apoptosis induction by the adenovirus E4-ORF4 protein. The protein is a component of adherens junctions, which are complexes that occur at cell-cell junctions and regulate cell growth and polarity. It is also involved in the formation of synapses between neurons.
Clinical significance[edit | edit source]
Mutations in the PVRL3 gene have been associated with Cleft lip and palate and ectodermal dysplasia in humans. The protein is also a potential target for cancer therapy, as it is overexpressed in several types of cancer, including breast cancer, ovarian cancer, and lung cancer.
Interactions[edit | edit source]
PVRL3 has been shown to interact with:
- Afadin, a protein that is involved in the formation of adherens junctions
- Nectin-1 and Nectin-2, which are other members of the Nectin family
- CD155, a protein that is involved in cell adhesion and serves as a receptor for poliovirus
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- PVRL3 at the National Center for Biotechnology Information
PVRL3 Resources | |
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Contributors: Prab R. Tumpati, MD