PVRL3

PVRL3 (PVR Like 3), also known as Nectin-3, is a protein that in humans is encoded by the PVRL3 gene. It is a member of the Nectin and Nectin-like (Necl) family of proteins, which function as cell adhesion molecules (CAMs) at adherens junctions.

Function

PVRL3 is a cell adhesion protein which is required for apoptosis induction by the adenovirus E4-ORF4 protein. The protein is a component of adherens junctions, which are complexes that occur at cell-cell junctions and regulate cell growth and polarity. It is also involved in the formation of synapses between neurons.

Clinical significance

Mutations in the PVRL3 gene have been associated with Cleft lip and palate and ectodermal dysplasia in humans. The protein is also a potential target for cancer therapy, as it is overexpressed in several types of cancer, including breast cancer, ovarian cancer, and lung cancer.

Interactions

PVRL3 has been shown to interact with:

• Afadin, a protein that is involved in the formation of adherens junctions
• Nectin-1 and Nectin-2, which are other members of the Nectin family
• CD155, a protein that is involved in cell adhesion and serves as a receptor for poliovirus

See also

• Nectin
• Cell adhesion
• Adherens junctions

External links

• PVRL3 at the National Center for Biotechnology Information

PVRL3 Resources
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