Palladin

Palladin is a protein that in humans is encoded by the PALLD gene. It is a cytoskeletal protein that plays a significant role in cell migration and cell adhesion, two processes that are essential for embryonic development and wound healing.

Function

Palladin is a component of actin-containing microfilaments and is involved in the control of cellular morphology and motility. It is also involved in the regulation of collagen deposition and extracellular matrix (ECM) assembly.

Clinical significance

Mutations in the PALLD gene are associated with idiopathic scoliosis, a condition characterized by a lateral curvature of the spine. Palladin has also been implicated in the progression of pancreatic cancer, as it is often overexpressed in this type of cancer and contributes to the invasive and migratory abilities of cancer cells.

Research

Research on Palladin has been focused on understanding its role in cell motility and adhesion, as well as its involvement in disease processes such as cancer and scoliosis. Studies have shown that Palladin is crucial for the formation of stress fibers, which are important for cell movement and structural integrity.

See also

• Actin
• Cell migration
• Cell adhesion
• Idiopathic scoliosis
• Pancreatic cancer