Focal adhesion
Focal Adhesion[edit | edit source]
Focal adhesion is a type of cell adhesion that is characterized by the binding of cells to the extracellular matrix (ECM). This process is crucial for various cellular functions, including cell migration, cell proliferation, and cell differentiation.
Structure[edit | edit source]
Focal adhesions are complex structures that consist of multiple proteins. The core components include integrins, talin, vinculin, and paxillin. These proteins interact with each other and with the ECM to form a physical link between the cytoskeleton and the ECM.
Function[edit | edit source]
Focal adhesions serve as the primary means for cells to adhere to the ECM. They also play a crucial role in signal transduction, transmitting signals from the ECM to the cell. This process is essential for various cellular functions, such as cell migration, cell proliferation, and cell differentiation.
Role in Disease[edit | edit source]
Abnormalities in focal adhesion can lead to various diseases, including cancer, fibrosis, and atherosclerosis. For example, in cancer, changes in focal adhesion can promote tumor growth and metastasis.
See Also[edit | edit source]
- Cell adhesion
- Extracellular matrix
- Integrin
- Talin
- Vinculin
- Paxillin
- Cytoskeleton
- Signal transduction
- Cancer
- Fibrosis
- Atherosclerosis
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD