Parnaparin sodium

Parnaparin sodium is a type of anticoagulant medication that is used to prevent and treat blood clots. It belongs to the class of drugs known as low molecular weight heparins (LMWHs), which are derived from the natural anticoagulant substance heparin. Parnaparin sodium works by inhibiting the formation of blood clots in the body, thereby reducing the risk of thrombosis and embolism.

Pharmacology

Parnaparin sodium exerts its anticoagulant effect by binding to antithrombin III, a protein that inhibits the activity of certain clotting factors in the blood. This binding enhances the inhibitory effect of antithrombin III on Factor Xa and Factor IIa, two key enzymes involved in the blood clotting process. By inhibiting these enzymes, parnaparin sodium prevents the formation of blood clots.

Clinical Use

Parnaparin sodium is used in the prevention and treatment of various conditions associated with thrombosis. These include deep vein thrombosis (DVT), pulmonary embolism (PE), and unstable angina or myocardial infarction in patients undergoing angioplasty. It is also used to prevent blood clots in patients undergoing surgery, particularly orthopedic surgery and abdominal surgery.

Side Effects

Like other anticoagulants, parnaparin sodium can cause bleeding complications. Other potential side effects include thrombocytopenia, a condition characterized by low platelet count, and osteoporosis with long-term use. Allergic reactions, such as skin rash and itching, may also occur.

Contraindications

Parnaparin sodium is contraindicated in patients with known hypersensitivity to heparin or LMWHs. It should also be used with caution in patients with a high risk of bleeding, such as those with active ulceration or angiodysplasia.

See Also

• Anticoagulant
• Low molecular weight heparins
• Antithrombin III
• Factor Xa
• Factor IIa
• Deep vein thrombosis
• Pulmonary embolism
• Angina
• Myocardial infarction
• Angioplasty
• Thrombocytopenia
• Osteoporosis