Paromomycin
(Redirected from Paromomycin sulfate)
An aminoglycoside antibiotic used to treat various infections
Paromomycin is an aminoglycoside antibiotic that is primarily used to treat certain types of parasitic infections. It is derived from the bacterium Streptomyces rimosus and is effective against a variety of protozoa and some bacteria.
Mechanism of Action[edit | edit source]
Paromomycin works by binding to the 16S rRNA of the 30S ribosomal subunit in bacteria, which interferes with the protein synthesis process. This binding causes the ribosome to misread the mRNA, leading to the production of faulty proteins and ultimately resulting in the death of the bacterial cell. In protozoa, the exact mechanism is not fully understood, but it is believed to disrupt protein synthesis in a similar manner.
Uses[edit | edit source]
Paromomycin is used to treat a variety of infections, including:
- Amoebiasis: It is effective against Entamoeba histolytica, the causative agent of amoebic dysentery.
- Leishmaniasis: Paromomycin is used in the treatment of visceral leishmaniasis, also known as kala-azar.
- Cryptosporidiosis: It is sometimes used to treat infections caused by Cryptosporidium species, particularly in immunocompromised patients.
- Giardiasis: Paromomycin can be used to treat infections caused by Giardia lamblia.
Administration[edit | edit source]
Paromomycin is typically administered orally in the form of capsules or tablets. The dosage and duration of treatment depend on the type and severity of the infection being treated. For certain infections, such as visceral leishmaniasis, paromomycin may be administered intramuscularly.
Side Effects[edit | edit source]
Common side effects of paromomycin include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. In some cases, it may cause ototoxicity, which can lead to hearing loss. Nephrotoxicity is another potential side effect, although it is less common.
Precautions[edit | edit source]
Paromomycin should be used with caution in patients with pre-existing renal impairment or hearing disorders. It is important to monitor kidney function and hearing during treatment, especially in patients receiving high doses or prolonged therapy.
[edit | edit source]
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD