Papaverine

From WikiMD's Wellness Encyclopedia

(Redirected from Pavabid)

Papaverine


Papaverine is a vasodilator and smooth muscle relaxant, originally derived from the Papaver somniferum (opium poppy) plant. It is a non-addictive derivative of the opium poppy, and is chemically unrelated to the opioids.

History[edit | edit source]

Papaverine was first isolated in 1848 by the French chemist François-Magendie. It was the first alkaloid to be isolated from the opium poppy. The name "papaverine" comes from papaver, the Latin name for the opium poppy.

Pharmacology[edit | edit source]

Papaverine works by inhibiting phosphodiesterase, leading to an increase in cyclic AMP and cyclic GMP in smooth muscle cells. This results in relaxation of the smooth muscle and vasodilation. It is used in the treatment of vasospasm, erectile dysfunction, and in vascular surgery.

Clinical uses[edit | edit source]

Papaverine is used clinically for the treatment of acute vasospasm, especially in the context of subarachnoid hemorrhage. It is also used in the treatment of erectile dysfunction, and is sometimes used in vascular surgery to prevent or treat vasospasm in blood vessels.

Side effects[edit | edit source]

Common side effects of papaverine include nausea, rash, and abdominal pain. In rare cases, it can cause hepatotoxicity or liver damage.

See also[edit | edit source]


WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD