Phaclofen
Phaclofen is a GABAB receptor antagonist drug that was first described in the literature in 1981. It is used in scientific research and has no known therapeutic use in humans.
History[edit | edit source]
Phaclofen was first described in the literature in 1981. It was developed as a research tool for studying the GABAB receptor, a type of G protein-coupled receptor that is found in the brain and spinal cord. The GABAB receptor is involved in a variety of physiological processes, including inhibition of neuronal activity and modulation of neurotransmitter release.
Pharmacology[edit | edit source]
Phaclofen acts as an antagonist at the GABAB receptor, meaning that it blocks the action of the neurotransmitter gamma-aminobutyric acid (GABA) at this receptor. This makes it a useful tool for studying the role of the GABAB receptor in various physiological processes.
Research Use[edit | edit source]
Phaclofen has been used in a variety of research studies to investigate the role of the GABAB receptor in the brain and spinal cord. For example, it has been used to study the role of this receptor in pain perception, memory formation, and the regulation of mood and anxiety.
See Also[edit | edit source]
References[edit | edit source]
| Phaclofen Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
