Philippa Marrack

File:Philippa Marrack

File:Philippa Marrack", Nature Medicine, v.10, n.12.

Philippa Marrack is a prominent immunologist known for her significant contributions to the field of immunology. She was born on June 28, 1945, in London, England. Marrack's research has been instrumental in advancing the understanding of T cells and their role in the immune system.

Early Life and Education

Philippa Marrack was born in London, where she developed an early interest in science. She pursued her undergraduate studies at Newnham College, Cambridge, where she earned a degree in biochemistry. She then completed her PhD at the University of London.

Career and Research

Marrack's career in immunology began with her postdoctoral work at the University of California, San Diego, where she worked with Richard Dutton. She later joined the faculty at National Jewish Health in Denver, Colorado, where she has conducted much of her groundbreaking research.

Marrack's research has focused on the mechanisms of T cell development and function. She is particularly known for her work on superantigens, which are a class of antigens that result in excessive activation of the immune system. Her studies have provided critical insights into how T cells recognize and respond to antigens, which has implications for understanding autoimmune diseases and developing vaccines.

Awards and Honors

Philippa Marrack has received numerous awards and honors for her contributions to immunology, including:

• The Lasker Award for Basic Medical Research
• The Louisa Gross Horwitz Prize
• Election to the National Academy of Sciences
• The Paul Ehrlich and Ludwig Darmstaedter Prize

Personal Life

Marrack is married to fellow immunologist John W. Kappler, with whom she has collaborated on many research projects. They have two children.

Legacy

Philippa Marrack's work has had a profound impact on the field of immunology. Her discoveries have advanced the understanding of the immune system and have paved the way for new treatments for autoimmune diseases and other immune-related conditions.

See Also

• Immunology
• T cells
• Superantigens
• Autoimmune diseases
• Vaccines