Photochemotherapy

Photochemotherapy is a type of therapy that combines the use of certain drugs and light to treat various diseases. This treatment method is primarily used in dermatology to manage skin conditions such as psoriasis, vitiligo, and eczema.

Overview

Photochemotherapy involves the administration of a photosensitizing drug followed by exposure to a specific wavelength of light. The interaction between the drug and light triggers a chemical reaction that can destroy abnormal cells or modify immune system responses. The two main types of photochemotherapy are PUVA therapy and UVB therapy.

PUVA Therapy

PUVA therapy, or psoralen plus ultraviolet A (UVA) therapy, involves the use of a photosensitizing drug called psoralen and UVA light. Psoralen is either taken orally or applied topically to the skin before UVA light exposure. The combination of psoralen and UVA light can slow down excessive skin cell growth and alleviate symptoms of skin diseases.

UVB Therapy

UVB therapy, or ultraviolet B therapy, uses UVB light to treat skin conditions. Unlike PUVA therapy, UVB therapy does not require the use of a photosensitizing drug. UVB light can slow down the growth of skin cells and is often used to treat moderate to severe psoriasis.

Risks and Side Effects

While photochemotherapy can be effective in treating certain skin conditions, it also carries potential risks and side effects. These may include skin cancer, cataracts, nausea, and itching. It is important for patients to discuss these risks with their healthcare provider before starting treatment.

See Also

• Photodynamic therapy
• Phototherapy
• Chemotherapy

References

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