Phototrexate
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Phototrexate is a photopharmacological agent[1][2] that behaves as light-regulated inhibitor of the dihydrofolate reductase (DHFR).[3][4] It is a photoisomerizable structural analogue of the chemotherapy agent methotrexate. Pharmacological effects of phototrexate can be switched on and off by UVA and visible light, respectively. Phototrexate is almost inactive in its trans configuration while it behaves as a potent antifolate in its cis configuration. It can also spontaneously self-deactivate in the dark.
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Contributors: Prab R. Tumpati, MD
