Phytomenadione

Phytomenadione (also known as vitamin K1 or phytonadione) is a vitamin found in food and used as a dietary supplement. As a supplement it is used to treat bleeding caused by warfarin, an anticoagulant medication. It is also used to prevent and treat vitamin K deficiency, a condition in which the body doesn't have enough vitamin K. It is given by injection into a vein or muscle or by mouth.

Sources

Phytomenadione is found in high amounts in green leafy vegetables, such as spinach and kale. Other sources include vegetable oils and some fruits.

Uses

Phytomenadione is used to prevent and treat vitamin K deficiency. This condition can lead to problems with blood clotting and increased bleeding. It is also used to reverse the effects of "blood-thinning" medications when too much is given.

Side effects

Common side effects include pain at the injection site and allergic reactions. Use during pregnancy appears to be safe. It is also safe to use during breastfeeding.

Mechanism of action

Phytomenadione works by providing the body with the necessary vitamin K it needs for blood clotting.

History

Phytomenadione was first made in 1939. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.

See also

• Vitamin K
• Vitamin K deficiency
• Warfarin

Phytomenadione

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  Vitamin K1 molecule
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  Biosynthesis of vitamin K1
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  Perfluorooctane 3D spacefill model