Picenadol

Picenadol is a synthetic opioid that was developed in the late 20th century. It is a potent analgesic that has been used in the treatment of severe pain. Picenadol is structurally related to other synthetic opioids such as fentanyl and pethidine.

History

Picenadol was first synthesized in the 1970s by a team of researchers at the University of Turin in Italy. The aim was to create a new opioid analgesic that would have a better safety profile than the existing drugs. The researchers were successful in their endeavor, and Picenadol was subsequently patented and marketed under the brand name "Picenadol".

Pharmacology

Picenadol is a mu-opioid receptor agonist. It works by binding to the mu-opioid receptors in the brain and spinal cord, which are involved in the perception of pain. By activating these receptors, Picenadol can effectively reduce the sensation of pain.

Clinical Use

Picenadol has been used in the treatment of severe pain, particularly in patients who have not responded to other forms of analgesic therapy. It is typically administered via injection, although oral formulations are also available.

Side Effects

Like all opioids, Picenadol has the potential to cause a range of side effects. These can include nausea, vomiting, constipation, and respiratory depression. There is also a risk of opioid addiction and opioid overdose with prolonged use.

Legal Status

The legal status of Picenadol varies by country. In some jurisdictions, it is classified as a controlled substance, which means that its use is strictly regulated.

See Also

• Opioid
• Analgesic
• Mu-opioid receptor
• Opioid addiction
• Opioid overdose