Piperazines

Piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. This group is a six-membered ring containing two nitrogen atoms at opposite positions in the ring.

History

Piperazines were originally synthesized in the late 19th century and their unique pharmacological properties were quickly recognized. The first pharmaceutical use of piperazine was as an anthelmintic to treat worm infestations in humans and animals.

Chemistry

Piperazines exist as small organic molecules that are composed of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. They can exist in either a free amine form or as salts with various acids. Piperazines are often used as building blocks in the synthesis of more complex chemical compounds.

Medical Uses

Piperazines are used in a variety of medical applications. They are used as anthelmintics to treat worm infestations in humans and animals. Some piperazines are also used as antiemetics, to prevent nausea and vomiting. Other piperazines have been used as antipsychotics, although these are not generally in use today due to side effects.

Side Effects

Like all medications, piperazines can have side effects. These can include nausea, vomiting, abdominal pain, and diarrhea. In rare cases, more serious side effects such as seizures, hallucinations, and severe allergic reactions can occur.

See Also

• Anthelmintic
• Antiemetic
• Antipsychotic

References

Piperazines Resources
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