Pleiotrophin
Pleiotrophin (PTN), also known as heparin-binding growth-associated molecule (HB-GAM), is a protein that in humans is encoded by the PTN gene. It is a secreted cytokine that has functions in neuronal development, angiogenesis, and tissue repair.
Function[edit | edit source]
Pleiotrophin is a growth factor with a key role in various biological processes. It is involved in the growth and development of different tissues, including the nervous system and blood vessels. It also plays a role in the process of wound healing and tissue repair.
Structure[edit | edit source]
The PTN gene is located on the short (p) arm of chromosome 7 at position 21.2. The protein encoded by this gene is a secreted cytokine that induces a variety of heparan sulfate proteoglycans and can stimulate the growth of several types of cells. This cytokine can also stimulate the proliferation of endothelial cells and promote angiogenesis.
Clinical significance[edit | edit source]
Pleiotrophin has been found to be overexpressed in a variety of cancers, including breast cancer, lung cancer, and pancreatic cancer. It is thought to promote tumor growth and angiogenesis, making it a potential target for cancer therapy.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- PTN gene at NCBI
- Pleiotrophin at UniProt
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