Porphine

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Porphine

Porphine is a heterocyclic compound that belongs to the group of porphyrins. It is a tetrapyrrole molecule consisting of four pyrrole rings connected by methine bridges. Porphine is an important building block in the synthesis of various porphyrin derivatives, including the well-known compound heme.

Structure and Properties[edit | edit source]

Porphine has a planar structure due to the presence of conjugated double bonds in its pyrrole rings. It is a cyclic tetrapyrrole with a total of 20 carbon atoms. The molecule has a central cavity that can accommodate metal ions, which is a characteristic feature of porphyrins.

Porphine exhibits interesting optical properties. It absorbs light in the visible region of the electromagnetic spectrum, giving it a deep purple color. This absorption is due to the presence of a conjugated system of double bonds, which allows for the delocalization of electrons.

Synthesis[edit | edit source]

Porphine can be synthesized through various methods, including the Rothemund synthesis and the Adler-Longo method. The Rothemund synthesis involves the condensation of pyrrole with an aldehyde, followed by oxidation to form the porphine ring. The Adler-Longo method, on the other hand, utilizes a metal-catalyzed reaction between pyrrole and a diketone to form the porphine ring.

Applications[edit | edit source]

Porphine and its derivatives have a wide range of applications in various fields. One of the most well-known applications is in the field of medicine, where porphyrins are used as photosensitizers in photodynamic therapy. This therapy involves the activation of porphyrins by light, which leads to the generation of reactive oxygen species that can selectively destroy cancer cells.

Porphine derivatives are also used in the synthesis of heme, a crucial component of hemoglobin and myoglobin. Heme is responsible for the binding and transport of oxygen in the blood and muscles, respectively.

See Also[edit | edit source]

References[edit | edit source]

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Contributors: Prab R. Tumpati, MD