Pralmorelin

Pralmorelin (also known as GHRP-2 or Growth Hormone Releasing Peptide-2) is a synthetic ghrelin analogue. It is a growth hormone secretagogue and ghrelin mimetic which is used as a diagnostic agent. It is used to test growth hormone secretion for the purpose of diagnosing growth hormone deficiency.

Pharmacology

Pralmorelin works by stimulating the pituitary gland to increase production of growth hormone. It is a ghrelin mimetic and an analogue of ghrelin, the hormone that regulates appetite and energy balance. Pralmorelin binds to the growth hormone secretagogue receptor (GHSR) in the pituitary gland and hypothalamus, where it acts as an agonist to stimulate the release of growth hormone.

Medical uses

Pralmorelin is used as a diagnostic agent to test for growth hormone deficiency. It is also being researched for its potential to treat conditions such as obesity, cachexia, and short stature. However, its use in these conditions is still experimental and not yet approved.

Side effects

The most common side effects of pralmorelin are similar to those of ghrelin, including increased appetite, flushing, and increased growth hormone levels. Other potential side effects include hypoglycemia, nausea, vomiting, and diarrhea.

See also

• Ghrelin
• Growth hormone
• Growth hormone deficiency
• Growth hormone secretagogue receptor
• Growth hormone therapy

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