Transthyretin
(Redirected from Prealbumin)
Transthyretin (TTR) is a protein that in humans is encoded by the TTR gene. It is a transport protein in the serum and cerebrospinal fluid that carries the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol.
Structure[edit | edit source]
Transthyretin is a tetramer of four identical subunits. Each subunit is a polypeptide chain made up of 127 amino acid residues. The four subunits form a central channel that can bind up to two molecules of thyroxine.
Function[edit | edit source]
The primary role of transthyretin is to transport thyroxine and retinol throughout the body. It binds to thyroxine in a 1:1 ratio and to retinol-binding protein in a 2:1 ratio. Transthyretin is synthesized primarily in the liver, but also in the choroid plexus of the brain and the retina.
Clinical significance[edit | edit source]
Mutations in the TTR gene can lead to various forms of transthyretin-related hereditary amyloidosis, a group of diseases characterized by the abnormal deposition of transthyretin amyloid fibrils in various tissues and organs. The most common form is familial amyloid polyneuropathy (FAP), which primarily affects the peripheral nervous system.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD