Metaraminol

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Metaraminol is a potent vasopressor and alpha-1 adrenergic receptor agonist. It is commonly used in the treatment of hypotension, particularly in cases of septic shock and anaphylaxis. Metaraminol works by constricting the blood vessels, thereby increasing blood pressure.

Pharmacology[edit | edit source]

Metaraminol acts primarily on alpha-1 adrenergic receptors, causing vasoconstriction and an increase in systemic vascular resistance. This results in an increase in blood pressure. It also has mild beta-1 adrenergic effects, which can increase heart rate and cardiac output.

Clinical Uses[edit | edit source]

Metaraminol is used in the treatment of hypotension, especially in cases where the hypotension is due to septic shock or anaphylaxis. It is also used in some surgical procedures to maintain blood pressure.

Side Effects[edit | edit source]

Common side effects of metaraminol include palpitations, tachycardia, anxiety, and headache. Less common side effects can include chest pain, dyspnea, and arrhythmias.

Contraindications[edit | edit source]

Metaraminol is contraindicated in patients with hypertension, pheochromocytoma, and those with a history of hyperthyroidism.

Drug Interactions[edit | edit source]

Metaraminol can interact with other medications, including monoamine oxidase inhibitors, tricyclic antidepressants, and beta blockers.

Dosage[edit | edit source]

The dosage of metaraminol is determined by the patient's weight, medical condition, and response to treatment.

See Also[edit | edit source]

Metaraminol Resources
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