Progastricsin
Progastricsin (also known as pepsinogen C) is a zymogen secreted by the gastric chief cells in the stomach. It is an aspartic protease that is activated to its active form, pepsin, in the acidic environment of the stomach.
Function[edit | edit source]
Progastricsin is involved in the digestion of proteins in the stomach. It is secreted as an inactive precursor, which is then converted into the active enzyme pepsin by the acidic pH of the stomach. This conversion involves the cleavage of a peptide bond in the progastricsin molecule, resulting in the active enzyme.
Clinical significance[edit | edit source]
Elevated levels of progastricsin in the blood can be indicative of certain gastric diseases, such as gastritis or gastric cancer. It is often measured in conjunction with other biomarkers to assess gastric function and health.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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