Progesterone synthesis inhibitor

Progesterone Synthesis Inhibitor is a type of drug that inhibits the production of progesterone, a hormone that plays a crucial role in the menstrual cycle and in maintaining the early stages of pregnancy.

Mechanism of Action

Progesterone synthesis inhibitors work by inhibiting the enzyme 3β-Hydroxysteroid dehydrogenase (3β-HSD), which is responsible for the conversion of pregnenolone to progesterone in the corpus luteum. By inhibiting this enzyme, these drugs prevent the synthesis of progesterone, thereby affecting the menstrual cycle and potentially preventing pregnancy.

Uses

Progesterone synthesis inhibitors are used in a variety of medical contexts. They are often used as a component of emergency contraception, where they can prevent pregnancy if taken within a certain time frame after unprotected sex. They are also used in the treatment of endometriosis, a condition in which tissue similar to the lining of the uterus grows outside of the uterus, causing pain and potentially leading to infertility.

Side Effects

Like all drugs, progesterone synthesis inhibitors can have side effects. These can include nausea, vomiting, abdominal pain, fatigue, and dizziness. In rare cases, they can cause severe allergic reactions.

See Also

• Progesterone
• 3β-Hydroxysteroid dehydrogenase
• Emergency contraception
• Endometriosis