Progressive macular hypomelanosis

Progressive macular hypomelanosis (PMH) is a skin condition characterized by the appearance of hypopigmented macules and patches, primarily on the trunk. It is a relatively common condition, particularly among young adults, and is more prevalent in females than in males. The exact cause of PMH is unknown, but it is believed to be associated with the presence of certain types of bacteria on the skin.

Symptoms and Diagnosis[edit | edit source]

The primary symptom of PMH is the appearance of small, hypopigmented macules on the skin. These macules, which are lighter than the surrounding skin, typically appear on the trunk, but can also occur on the neck, arms, and legs. Over time, these macules may coalesce to form larger patches of hypopigmentation.

Diagnosis of PMH is typically based on the characteristic appearance of the skin lesions. In some cases, a skin biopsy may be performed to rule out other conditions. Wood's lamp examination, a diagnostic technique that uses ultraviolet light to highlight changes in the skin, may also be used.

Treatment[edit | edit source]

Treatment for PMH primarily involves the use of topical therapies to help restore skin pigmentation. These may include retinoids, antibiotics, and benzoyl peroxide. In some cases, phototherapy using ultraviolet light may also be beneficial.

Epidemiology[edit | edit source]

PMH is more common in females than in males, and typically affects young adults. It has been reported in individuals of all ethnic backgrounds, but appears to be more common in those with darker skin.

Research and Future Directions[edit | edit source]

Research into PMH is ongoing, with a particular focus on understanding the role of bacteria in the development of the condition. Future treatment strategies may include the use of probiotics or other interventions to modify the skin microbiome.