Oxyphenisatine

Oxyphenisatine is a laxative that was previously used for the treatment of constipation. It was withdrawn from the market due to its potential for causing liver damage.

History

Oxyphenisatine was first synthesized in the 1960s and was marketed as a laxative under various brand names. However, it was withdrawn from the market in the 1970s due to concerns about its safety. Specifically, it was found to cause liver damage in some patients, which led to its withdrawal.

Pharmacology

Oxyphenisatine is a stimulant laxative, which means it works by stimulating the muscles in the intestine to increase bowel movements. It is not absorbed into the bloodstream, so its effects are localized to the intestines.

Side Effects

The most serious side effect of oxyphenisatine is hepatotoxicity, or liver damage. This can occur even with normal doses of the drug. Other side effects can include nausea, vomiting, abdominal pain, and diarrhea.

Withdrawal from the Market

Oxyphenisatine was withdrawn from the market in the 1970s due to concerns about its safety. Specifically, it was found to cause liver damage in some patients, which led to its withdrawal. Despite its withdrawal, oxyphenisatine is still occasionally used in some countries, although its use is generally discouraged due to the risk of liver damage.

See Also

• List of withdrawn drugs
• Hepatotoxicity
• Laxative