Propentofylline

Propentofylline is a xanthine derivative that is used as a vasodilator. It is a phosphodiesterase inhibitor and a adenosine reuptake inhibitor. Propentofylline is used in the treatment of dementia and Alzheimer's disease, and it has been investigated for use in the treatment of cerebrovascular disease and vascular dementia.

Pharmacology

Propentofylline is a xanthine derivative that acts as a vasodilator. It inhibits phosphodiesterase and adenosine reuptake, which leads to an increase in cyclic AMP and cyclic GMP in the brain. This results in vasodilation and an increase in blood flow to the brain.

Clinical uses

Propentofylline has been used in the treatment of dementia and Alzheimer's disease. It has been shown to improve cognitive function and reduce symptoms of dementia in clinical trials. It has also been investigated for use in the treatment of cerebrovascular disease and vascular dementia.

Side effects

The most common side effects of propentofylline are gastrointestinal disturbances, such as nausea and vomiting. Other side effects can include headache, dizziness, and palpitations.

See also

• Xanthine
• Vasodilator
• Phosphodiesterase inhibitor
• Adenosine reuptake inhibitor
• Dementia
• Alzheimer's disease
• Cerebrovascular disease
• Vascular dementia

Propentofylline Resources
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