Propentofylline
Propentofylline is a xanthine derivative that is used as a vasodilator. It is a phosphodiesterase inhibitor and a adenosine reuptake inhibitor. Propentofylline is used in the treatment of dementia and Alzheimer's disease, and it has been investigated for use in the treatment of cerebrovascular disease and vascular dementia.
Pharmacology[edit | edit source]
Propentofylline is a xanthine derivative that acts as a vasodilator. It inhibits phosphodiesterase and adenosine reuptake, which leads to an increase in cyclic AMP and cyclic GMP in the brain. This results in vasodilation and an increase in blood flow to the brain.
Clinical uses[edit | edit source]
Propentofylline has been used in the treatment of dementia and Alzheimer's disease. It has been shown to improve cognitive function and reduce symptoms of dementia in clinical trials. It has also been investigated for use in the treatment of cerebrovascular disease and vascular dementia.
Side effects[edit | edit source]
The most common side effects of propentofylline are gastrointestinal disturbances, such as nausea and vomiting. Other side effects can include headache, dizziness, and palpitations.
See also[edit | edit source]
- Xanthine
- Vasodilator
- Phosphodiesterase inhibitor
- Adenosine reuptake inhibitor
- Dementia
- Alzheimer's disease
- Cerebrovascular disease
- Vascular dementia
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Contributors: Prab R. Tumpati, MD
