Protease inhibitor
Protease inhibitors (PIs) are a class of antiviral drugs that are widely used to treat HIV/AIDS and hepatitis C. PIs prevent viral replication by inhibiting the activity of protease, an enzyme used by HIV and HCV to cleave nascent proteins for final assembly of new virions.
Mechanism of action[edit | edit source]
Protease inhibitors work by binding to the enzyme protease, making it impossible for the virus to cleave nascent proteins for final assembly of new virions. This prevents the virus from replicating within the body.
Types of Protease Inhibitors[edit | edit source]
There are several types of protease inhibitors, including those used to treat HIV and those used to treat hepatitis C. Some of the most common protease inhibitors include:
- Atazanavir (Reyataz)
- Darunavir (Prezista)
- Fosamprenavir (Lexiva, Telzir)
- Indinavir (Crixivan)
- Lopinavir (in Kaletra)
- Nelfinavir (Viracept)
- Ritonavir (Norvir)
- Saquinavir (Invirase)
- Tipranavir (Aptivus)
Side Effects[edit | edit source]
Like all medications, protease inhibitors can cause side effects. Some of the most common side effects include:
- Nausea
- Diarrhea
- Unusual taste in the mouth
- Feeling weak or tired
- Changes in the distribution of fat on the body
See Also[edit | edit source]
| Protease inhibitor Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
