Pyrazolanthrone

Pyrazolanthrone, also known as SP600125, is a biochemical compound that functions as an anthrapyrazolone inhibitor. It is primarily used in biomedical research to study signal transduction pathways.

Chemical Structure and Properties

Pyrazolanthrone is a synthetic compound that belongs to the anthrapyrazolone class of chemicals. It has a complex structure that includes a pyrazole ring fused to an anthraquinone moiety. The molecular formula of pyrazolanthrone is C₁₄H₈N₂O. It is a yellow crystalline solid at room temperature.

Biological Activity

Pyrazolanthrone is a potent and selective inhibitor of c-Jun N-terminal kinases (JNKs). JNKs are a group of protein kinases that play a crucial role in signal transduction pathways, particularly those involved in cell proliferation, apoptosis, and inflammation. By inhibiting JNKs, pyrazolanthrone can modulate these pathways and potentially influence various biological processes and disease states.

Medical Research and Applications

Due to its ability to inhibit JNKs, pyrazolanthrone has been extensively used in biomedical research. It has been employed in studies investigating the role of JNKs in diseases such as cancer, neurodegenerative diseases, and autoimmune diseases. Pyrazolanthrone's potential therapeutic applications are currently under investigation.

Safety and Toxicity

Like all biochemical compounds, pyrazolanthrone should be handled with care. It may cause skin and eye irritation, and prolonged exposure may lead to more serious health effects. Always follow safety guidelines when handling pyrazolanthrone.

See Also

• Anthrapyrazolone
• c-Jun N-terminal kinases
• Signal transduction