QMPSB
QMPSB (Quinolinate Phosphoribosyltransferase Small Subunit B) is a protein that in humans is encoded by the QMPSB gene. This protein is part of the quinolinic acid pathway, which is involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+).
Function[edit | edit source]
The QMPSB protein is a component of the quinolinate phosphoribosyltransferase (QPRTase) complex, which catalyzes the conversion of quinolinic acid and 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinic acid mononucleotide (NaMN) and pyrophosphate. This is a key step in the biosynthesis of NAD+.
Clinical significance[edit | edit source]
Mutations in the QMPSB gene have been associated with various neurological disorders, including Huntington's disease and Alzheimer's disease. This is due to the role of quinolinic acid in the production of NAD+, which is essential for cellular energy production and DNA repair.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
