Quinfamide
Antiparasitic medication
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Quinfamide is an antiparasitic medication primarily used in the treatment of amoebiasis, a parasitic infection of the intestines caused by the protozoan Entamoeba histolytica. It is particularly effective against the cyst form of the parasite, which is responsible for transmission and infection.
Mechanism of Action[edit | edit source]
Quinfamide works by inhibiting the DNA synthesis of the Entamoeba histolytica cysts, thereby preventing their replication and survival. This action disrupts the life cycle of the parasite, leading to its eventual elimination from the host's body. The drug is specifically designed to target the cysts, which are the dormant and resistant form of the parasite, making it effective in preventing the spread of infection.
Pharmacokinetics[edit | edit source]
Quinfamide is administered orally and is known for its poor absorption in the gastrointestinal tract, which is beneficial as it allows the drug to act directly in the intestines where the Entamoeba histolytica resides. The drug is minimally metabolized and is excreted primarily in the feces.
Clinical Use[edit | edit source]
Quinfamide is used in the treatment of intestinal amoebiasis, particularly in cases where the infection is asymptomatic or in the cystic stage. It is not typically used for invasive forms of amoebiasis, such as amoebic dysentery or liver abscess, where other medications like metronidazole are preferred.
Side Effects[edit | edit source]
The side effects of quinfamide are generally mild and may include nausea, abdominal pain, and diarrhea. Due to its limited absorption, systemic side effects are rare.
Synthesis[edit | edit source]
The synthesis of quinfamide involves the chemical modification of a quinoline derivative. The process includes the introduction of functional groups that enhance its antiparasitic activity and specificity for the Entamoeba histolytica cysts.
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