Quisqualamine

Quisqualamine is a neurotoxin that is derived from the seeds of the Quisqualis indica plant, also known as the Chinese honeysuckle. It is a potent acetylcholinesterase inhibitor, which means it can block the action of the enzyme that breaks down acetylcholine in the synapses between nerve cells. This can lead to an increase in the concentration of acetylcholine, which can have various effects on the body, including increased muscle contractions and stimulation of the parasympathetic nervous system.

History

Quisqualamine was first isolated in 1930 by the French chemist Robert H. Elderfield, who was studying the chemical composition of the seeds of the Quisqualis indica plant. He named the compound after the plant from which it was derived.

Pharmacology

Quisqualamine is a reversible inhibitor of acetylcholinesterase, which means it can bind to the enzyme and prevent it from breaking down acetylcholine, but it can also be removed from the enzyme, allowing it to resume its normal function. This makes quisqualamine a potentially useful drug for conditions that are caused by a deficiency of acetylcholine, such as Alzheimer's disease and myasthenia gravis.

Toxicity

The toxicity of quisqualamine is due to its ability to increase the concentration of acetylcholine in the synapses between nerve cells. This can lead to overstimulation of the muscles and the parasympathetic nervous system, which can cause symptoms such as muscle weakness, blurred vision, and slow heart rate. In severe cases, it can lead to respiratory failure and death.

See also

• Neurotoxin
• Acetylcholinesterase inhibitor
• Quisqualis indica

Quisqualamine Resources
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