R-tPA
R-tPA or Recombinant tissue plasminogen activator is a thrombolytic drug, one of the pharmaceuticals that promotes thrombolysis. It is produced through recombinant DNA technology, and is used to treat conditions like acute ischemic stroke and myocardial infarction (heart attack).
Mechanism of Action[edit | edit source]
R-tPA works by catalyzing the conversion of plasminogen to plasmin. Plasmin is an enzyme that breaks down fibrin clots, a type of blood clot. This action can help to restore blood flow in the affected area.
Uses[edit | edit source]
R-tPA is used in the treatment of acute ischemic stroke and myocardial infarction. It can also be used in cases of massive pulmonary embolism.
Side Effects[edit | edit source]
The most common side effect of R-tPA is bleeding. Other side effects can include allergic reactions, low blood pressure, and edema.
Contraindications[edit | edit source]
R-tPA should not be used in patients with active internal bleeding, recent surgery, or a history of stroke within the past three months.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
