RAD51C

RAD51C

RAD51C is a gene that encodes a protein involved in the homologous recombination and repair of DNA. This protein is a member of the RAD51 family, which plays a critical role in maintaining genomic stability by repairing DNA double-strand breaks. Mutations in the RAD51C gene have been associated with an increased risk of certain cancers, particularly breast and ovarian cancer.

Function

The RAD51C protein is essential for the repair of DNA double-strand breaks through homologous recombination, a process that ensures the accurate repair of DNA by using a homologous sequence as a template. RAD51C forms a complex with other RAD51 paralogs, including RAD51B, RAD51D, and XRCC2, to facilitate the search for homology and strand pairing during the repair process.

Clinical Significance

Mutations in the RAD51C gene have been linked to an increased susceptibility to breast and ovarian cancer. RAD51C is considered a moderate-risk gene for hereditary breast and ovarian cancer syndrome. Genetic testing for RAD51C mutations can be part of a comprehensive assessment for individuals with a family history of these cancers.

Research

Ongoing research is focused on understanding the precise mechanisms by which RAD51C and its associated complexes contribute to DNA repair and how mutations in this gene lead to cancer predisposition. Studies are also exploring potential therapeutic strategies that target RAD51C-related pathways in cancer treatment.

Also see

• DNA repair
• Homologous recombination
• Breast cancer
• Ovarian cancer
• RAD51
• BRCA1
• BRCA2