RAMP2
RAMP2 or Receptor Activity Modifying Protein 2 is a protein that in humans is encoded by the RAMP2 gene. It is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus.
Function[edit | edit source]
RAMP2, along with RAMP1 and RAMP3, are necessary for transport of the calcitonin gene-related peptide receptor component protein to the cell surface. RAMP2 is able to interact with two different proteins: calcitonin-receptor-like receptor and calcitonin receptor to create two different receptors with different functions.
Clinical Significance[edit | edit source]
Mutations in the RAMP2 gene have been associated with pulmonary hypertension. Studies have shown that RAMP2 plays a crucial role in maintaining vascular integrity. It is also involved in the pathogenesis of various cardiovascular diseases, including hypertension, heart failure, and atherosclerosis.
Research[edit | edit source]
Research on RAMP2 is ongoing, with studies focusing on its role in cardiovascular diseases and potential as a therapeutic target.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD