RHAG
RHAG is a gene that in humans is encoded by the RHAG locus. This gene is a member of the Rh family of genes, which are responsible for the production of the Rh blood group system antigens. The Rh blood group system is one of the most complex human blood group systems and has significant importance in transfusion medicine.
Function[edit | edit source]
The RHAG gene provides instructions for making a protein called Rh-associated glycoprotein (RhAG). This protein is a component of the Rh blood group system, which consists of approximately 50 different antigens. The RhAG protein is found in red blood cells and is involved in the transport of ammonia and carbon dioxide across the red blood cell membrane.
Clinical significance[edit | edit source]
Mutations in the RHAG gene can cause Rh deficiency syndrome, a rare condition characterized by a lack of Rh antigens on the surface of red blood cells. This condition can lead to hemolytic anemia, a disorder in which red blood cells are destroyed faster than they can be replaced.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
