RNF14

RNF14 (Ring Finger Protein 14) is a protein that in humans is encoded by the RNF14 gene. This protein is a part of the ARA54 subfamily of RING finger proteins, a family characterized by the presence of a RING finger domain, a specialized type of zinc finger that binds two atoms of zinc.

Function

RNF14 is a multi-functional protein that plays a role in several biological processes. It is involved in the regulation of androgen receptor activity, apoptosis, and cell cycle progression. The protein is also implicated in the ubiquitin-proteasome pathway, a cellular mechanism responsible for protein degradation.

Structure

The RNF14 protein contains a RING finger domain, which is a common feature of the RING finger protein family. This domain is responsible for the protein's E3 ubiquitin ligase activity, which allows it to tag other proteins for degradation by the proteasome.

Clinical Significance

Alterations in the RNF14 gene have been associated with various diseases. For instance, mutations in this gene have been linked to cancer, particularly breast cancer and prostate cancer. The protein's role in regulating androgen receptor activity also suggests a potential involvement in androgen insensitivity syndrome.

Research

Research into RNF14 is ongoing, with studies focusing on its role in cancer and potential as a therapeutic target. Understanding the function and regulation of this protein could lead to new treatments for diseases associated with RNF14 alterations.

See Also

• RING finger domain
• Androgen receptor
• Ubiquitin-proteasome pathway