RPLP0

RPLP0, also known as ribosomal protein lateral stalk subunit P0, is a protein that in humans is encoded by the RPLP0 gene. It is a component of the 60S ribosomal subunit in eukaryotic cells, playing a critical role in the protein synthesis process. RPLP0 is part of the ribosomal P-stalk, a structure that interacts with elongation factors during translation, facilitating the synthesis of polypeptides.

Function

RPLP0 is essential for protein biosynthesis, serving as a core component of the ribosome, which is the cellular machinery responsible for translating mRNA into proteins. It is involved in the formation of the peptidyl transferase center, where amino acids are linked together to form proteins. The P-stalk, where RPLP0 is located, is crucial for recruiting elongation factors to the ribosome, enhancing the efficiency of protein synthesis.

Structure

The structure of RPLP0 includes several domains that are important for its function within the ribosome. It is part of the larger P-stalk complex, which also includes other ribosomal proteins such as RPLP1 and RPLP2. These proteins work together to bind elongation factors and facilitate their interaction with the ribosome.

Clinical Significance

Alterations in the expression levels of RPLP0 have been associated with various cancers and disorders. Due to its fundamental role in protein synthesis, changes in RPLP0 function or expression can disrupt cellular homeostasis and lead to disease. Research is ongoing to understand the potential of targeting RPLP0 in cancer therapy.

See Also

• Ribosome
• Protein synthesis
• Eukaryotic translation