Remitting seronegative symmetrical synovitis with pitting edema

Remitting Seronegative Symmetrical Synovitis with Pitting Edema (often abbreviated as RS3PE) is a rare clinical syndrome characterized by the onset of acute inflammation in the joints (synovitis) and swelling (edema) in the extremities. The condition is typically seronegative, meaning that it does not show the presence of certain antibodies often associated with rheumatic diseases.

Symptoms

The primary symptoms of RS3PE include sudden onset of pain and swelling in the joints, particularly in the hands and feet. The swelling often results in a condition known as pitting edema, where pressure applied to the skin leaves a dent that takes some time to fill back in. Other symptoms may include stiffness in the affected joints, fatigue, and in some cases, mild fever.

Causes

The exact cause of RS3PE is unknown. However, it is believed to be associated with various underlying conditions such as cancer, infections, and autoimmune diseases. Some studies suggest that it may be triggered by an overactive immune response.

Diagnosis

Diagnosis of RS3PE is primarily based on clinical examination and the patient's medical history. Laboratory tests may be conducted to rule out other conditions. Imaging tests such as ultrasound and magnetic resonance imaging (MRI) may also be used to assess the extent of inflammation and edema.

Treatment

Treatment for RS3PE typically involves the use of nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce inflammation and pain. In severe cases, corticosteroids may be prescribed. Physical therapy may also be recommended to improve joint function.

Prognosis

The prognosis for RS3PE is generally good, with most patients experiencing remission within a few months of treatment. However, the condition can recur in some cases.

File:Hand with pitting edema.jpg

Pitting edema, a common symptom of RS3PE

See also

• Rheumatology
• Edema
• Synovitis