Rab4b-egln2 readthrough (nmd candidate)

Rab4b-egln2 readthrough (nmd candidate) is a protein that in humans is encoded by the RAB4B-EGLN2 gene. This gene is a readthrough candidate, where an overlapping nuclear transcription event between the upstream gene for RAB4B and the downstream gene for EGLN2 results in a fusion protein.

Function

The RAB4B-EGLN2 gene is a member of the RAS oncogene family. The RAS oncogene family is a class of genes that are commonly mutated in cancers. The protein encoded by this gene is a small GTPase that regulates intracellular membrane trafficking in the late endocytic pathway.

The EGLN2 gene encodes a member of the hypoxia-inducible factor (HIF) hydroxylase family. The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in HIF alpha proteins.

Clinical significance

Mutations in the RAB4B-EGLN2 gene have been associated with various types of cancer, including lung cancer and breast cancer. The protein encoded by this gene may play a role in tumor growth and progression.

See also

• RAB4B
• EGLN2
• Nonsense-mediated decay

References

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