Rectal administration

Rectal administration is a route of administration where medications are inserted into the rectum. This method is often used when a patient has difficulty swallowing, is vomiting, or the drug needs to be delivered directly to the lower gastrointestinal tract.

Overview

Rectal administration can be used for both systemic and local effects. Systemic effects involve the drug being absorbed into the bloodstream and distributed throughout the body. Local effects are limited to the area of the rectum and colon, where the drug can treat conditions such as hemorrhoids, anal fissures, and local infections.

Advantages

The rectal route has several advantages over other routes of administration. It bypasses the first pass effect, which can lead to a higher bioavailability of the drug. It is also useful for patients who are unable to swallow or are nauseous. Additionally, it can be used for drugs that are destroyed by stomach acid.

Disadvantages

Despite its advantages, rectal administration also has several disadvantages. It can be uncomfortable and embarrassing for some patients. The absorption of the drug can be unpredictable and variable. There is also a risk of damage to the rectal tissue if the drug is not administered properly.

Drugs Administered Rectally

Several types of drugs can be administered rectally. These include antiemetics, analgesics, antipyretics, antibiotics, and sedatives. The form of the drug can vary, with suppositories and enemas being the most common.

Procedure

The procedure for rectal administration involves the patient lying on their side with their upper leg drawn towards their chest. The medication is then inserted into the rectum, usually with a lubricated finger or applicator. The patient should remain in this position for at least a few minutes to allow the medication to be absorbed.

See Also

• Oral administration
• Intravenous administration
• Subcutaneous administration
• Intramuscular administration

Rectal administration Resources
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