Reprimo
Reprimo is a gene that in humans is encoded by the RPRM gene. This gene is a potential tumor suppressor and is a major mediator of the p53/TP53 tumor suppressor pathway. As a DNA damage inducible gene, it is involved in the induction of G2/M arrest.
Function[edit | edit source]
The protein encoded by the Reprimo gene is a cytoplasmic protein, which is capable of inducing cell cycle arrest in G2/M phase. This protein is a DNA damage-inducible gene and may play a role in the cellular response to DNA damage. It is also suggested to function as a tumor suppressor.
Clinical significance[edit | edit source]
Alterations in the Reprimo gene are associated with gastric cancer. The gene is frequently silenced in gastric cancer due to promoter hypermethylation, and this silencing is associated with tumor progression.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
