Reviparin sodium

Reviparin sodium is a low molecular weight heparin (LMWH) that is primarily used as an anticoagulant for the prevention and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE). It is a derivative of heparin, a naturally occurring anticoagulant produced by basophils and mast cells.

Pharmacology

Reviparin sodium works by enhancing the inhibition of Factor Xa and thrombin by increasing antithrombin III activity. This prevents the conversion of fibrinogen to fibrin, thereby inhibiting blood clot formation. It has a higher ratio of anti-Factor Xa to anti-thrombin activity compared to unfractionated heparin, which may contribute to its superior efficacy and safety profile.

Clinical Use

Reviparin sodium is indicated for the prevention of DVT and PE in patients undergoing orthopedic or abdominal surgery, and in acutely ill medical patients at risk for thromboembolic complications. It is also used for the treatment of acute DVT and PE, and for the prevention of clotting in the extracorporeal circulation during hemodialysis.

Side Effects

The most common side effect of reviparin sodium is bleeding. Other side effects may include thrombocytopenia, hypersensitivity reactions, and, rarely, osteoporosis with long-term use.

Contraindications

Reviparin sodium is contraindicated in patients with active major bleeding, severe thrombocytopenia, or known hypersensitivity to reviparin sodium or to any of its components. It should be used with caution in patients with a high risk of bleeding, such as those with severe hypertension, peptic ulcer disease, or recent brain, spinal, or ophthalmic surgery.

Dosage and Administration

The dosage of reviparin sodium is individualized based on the patient's weight, indication, and renal function. It is administered subcutaneously, usually once or twice daily.

See Also

• Low molecular weight heparin
• Anticoagulant
• Deep vein thrombosis
• Pulmonary embolism
• Heparin
• Factor Xa
• Thrombin
• Fibrin
• Hemodialysis
• Thrombocytopenia
• Osteoporosis