Rho(D) immune globulin

Rho(D) immune globulin (also known as Anti-D, RhIG, or RhD immune globulin) is a medication used to prevent Rh disease in pregnancies and other situations where there is a risk of RhD antigen sensitization.

Kleihauer Positive

Overview

Rho(D) immune globulin is a sterile solution made from human plasma that is used to prevent an immune response to Rh positive blood in people who have Rh negative blood. It works by binding any RhD positive red blood cells before the immune system can produce an immune response against them.

Medical Uses

Rho(D) immune globulin is used in a variety of medical situations. The most common use is during pregnancy, when a Rh negative woman is carrying a Rh positive fetus. Without treatment, the woman's body may produce antibodies against the fetus's blood, leading to hemolytic disease of the newborn. Rho(D) immune globulin is also used in cases of miscarriage, abortion, ectopic pregnancy, and blood transfusion.

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Administration

Rho(D) immune globulin is typically administered via intramuscular injection. The timing and dosage depend on the specific situation and the individual patient's needs.

Side Effects

Common side effects of Rho(D) immune globulin include pain at the injection site, fever, and headache. More serious side effects, such as allergic reactions, are rare.

History

Rho(D) immune globulin was first introduced in the 1960s. Prior to its introduction, Rh disease was a significant cause of death in newborns. The development and widespread use of Rho(D) immune globulin has greatly reduced the incidence of Rh disease.

See Also

• Rh blood group system
• Hemolytic disease of the newborn
• Blood transfusion