Ribostamycin

Ribostamycin is an aminoglycoside antibiotic that is derived from Streptomyces ribosidificus. It is used in the treatment of various bacterial infections, particularly those caused by Gram-negative bacteria. Ribostamycin works by binding to the bacterial ribosome, inhibiting protein synthesis and thereby killing the bacteria.

History

Ribostamycin was first isolated in 1968 from Streptomyces ribosidificus, a species of actinobacteria that is found in soil. The discovery of ribostamycin was part of a larger effort to find new antibiotics that could be used to treat drug-resistant bacterial infections.

Medical uses

Ribostamycin is used to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections, and skin infections. It is particularly effective against Gram-negative bacteria, such as Escherichia coli and Klebsiella pneumoniae.

Mechanism of action

Ribostamycin works by binding to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis. This prevents the bacteria from growing and reproducing, effectively killing them.

Side effects

Like other aminoglycoside antibiotics, ribostamycin can cause ototoxicity and nephrotoxicity. Other potential side effects include allergic reactions and gastrointestinal distress.

See also

• Aminoglycoside
• Antibiotic resistance
• Protein synthesis

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