Rimeporide

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Rimeporide skeletal

Rimeporide

Rimeporide is a pharmaceutical drug that belongs to the class of potassium-sparing diuretics. It is primarily used in the treatment of hypertension and congestive heart failure. Rimeporide works by inhibiting the sodium-potassium-chloride cotransporter in the distal convoluted tubule of the kidney, leading to increased excretion of sodium and water while retaining potassium.

Mechanism of Action

Rimeporide exerts its diuretic effects by selectively blocking the sodium-potassium-chloride cotransporter in the kidney. By inhibiting this transporter, rimeporide reduces the reabsorption of sodium and chloride ions, leading to increased excretion of these ions in the urine. This results in a decrease in extracellular fluid volume and blood pressure.

Clinical Uses

Rimeporide is primarily indicated for the management of hypertension and congestive heart failure. It is often used in combination with other antihypertensive medications to achieve optimal blood pressure control. In patients with heart failure, rimeporide helps reduce fluid retention and improve cardiac function.

Side Effects

Common side effects associated with rimeporide therapy include hyperkalemia (elevated potassium levels), dizziness, headache, and gastrointestinal disturbances. In rare cases, rimeporide may cause allergic reactions or electrolyte imbalances.

Contraindications

Rimeporide is contraindicated in patients with hyperkalemia, severe renal impairment, and Addison's disease. It should not be used in combination with other potassium-sparing diuretics or potassium supplements due to the risk of severe hyperkalemia.

Interactions

Rimeporide may interact with other medications such as ACE inhibitors, angiotensin receptor blockers, and nonsteroidal anti-inflammatory drugs, leading to an increased risk of hyperkalemia. Patients should inform their healthcare provider about all medications they are taking before starting rimeporide therapy.