Ring finger protein 167

Ring finger protein 167 (RNF167) is a protein that in humans is encoded by the RNF167 gene. The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.

Function

The RNF167 protein is a member of the RING finger proteins family, which are characterized by the presence of a RING finger motif. This motif is a specialized type of Zinc finger that binds two atoms of zinc and is likely involved in mediating protein-protein interactions.

RNF167 is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein plays a role in the control of endosomal trafficking.

Clinical significance

Alterations in the RNF167 gene have been associated with various diseases. For instance, mutations in this gene have been linked to neurodegenerative diseases due to its role in the ubiquitin-proteasome system, a crucial pathway for protein degradation in cells.

See also

• RING finger domain
• Ubiquitin-protein ligase
• Zinc finger