Rinucumab
Rinucumab is a monoclonal antibody designed for the treatment of age-related macular degeneration (AMD). It was developed by Regeneron Pharmaceuticals and Bayer. Rinucumab works by inhibiting the action of platelet-derived growth factor (PDGF), which is believed to contribute to the development of AMD.
History[edit | edit source]
Rinucumab was first developed by Regeneron Pharmaceuticals and Bayer. In 2016, the companies announced that a Phase II study of the drug had failed to meet its primary endpoint. The study was designed to evaluate the efficacy and safety of rinucumab when used in combination with aflibercept, another drug developed by Regeneron and Bayer for the treatment of AMD.
Mechanism of Action[edit | edit source]
Rinucumab is a monoclonal antibody that targets and inhibits the action of PDGF. PDGF is a protein that promotes the growth of blood vessels, including those that contribute to the development of AMD. By inhibiting PDGF, rinucumab is believed to slow the progression of AMD.
Clinical Trials[edit | edit source]
In 2016, a Phase II clinical trial of rinucumab was conducted. The trial involved patients with AMD who were treated with a combination of rinucumab and aflibercept. However, the trial failed to meet its primary endpoint, which was to improve visual acuity in the patients.
Future Development[edit | edit source]
Following the failure of the Phase II trial, the future development of rinucumab is uncertain. Regeneron and Bayer have not announced any plans to continue the development of the drug.
See Also[edit | edit source]
- Monoclonal antibodies
- Age-related macular degeneration
- Platelet-derived growth factor
- Regeneron Pharmaceuticals
- Bayer
Rinucumab Resources | |
---|---|
|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD